1 ةمجرت ةملك ةداعس ذاتسلأا روتكدلا دنانريف يربلا زئافلا ةزئاجب كلملا لصيف ةيملاعلا بطلل )كرا تشلااب( ماعل م1002/ه2418 نينثلاا ه2418/3/18 قفاوملا م1002

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1 1 ةمجرت ةملك ةداعس ذاتسلأا روتكدلا دنانر يربلا زئافلا ةزئاجب ةيملاعلا بطلل )كرا تشلااب( ماعل م1002/ه2418 نينثلاا ه2418/3/18 قفاوملا م1002/4/21 بحاص ومسلا ي ريملأا ناطلس نب دبع زيزعلا يلو دهعلا بئان سيئر سلجم ءرا زولا ريزو عافدلا نرا يطلاو شتفملاو ماعلا باحصأ ومسلا ءرا ملأا باحصأ ةليضفلا يلاعملاو ةداعسلاو هنإ فرشل لا ليثم هل نأ م لستأ ةزئاج ةيملاعلا دع ت اجذومن اخسرا لمعلل يريخلا يبرعلا.يملاسلإاو وهو فرش ميظع اضيأ نأ مضنأ ةبكوك نيزئافلا نيزيمتملا ةزئاجلاب ذ اهئاشنإ ماع م2721 اصوصخو نيذلا اوزاف اهب اذه ماعلا ريهاشم ءاملعلا.يركفملاو يح هذه ةزئاجلا سيل افرش يل يدحو بسحف لب ريدقت ردصمو ماهلإ تائملل يئلامز نينواعتملاو يعم ربع تاونسلا و رداصم يرخف اضيأ نأ يرايتخا هذهل ةزئاجلا فيرشت ةعماجل ل ڤلا ا لمعأ اه ةنيدملو كبيوك مدقأ ةنيدم اكيرمأ ةيلامشلا ميقأ.اه دقل ناك ده ذ ءدب يتسرا د ةيلك كبيوك ةيلكو بطلا ةعماج ل ڤلا ا ةعباتمو يثاحبأ امل قوف هرا وتكدلا ةعماج جدربمك ةيناطيربلا وه ثحبلا نع فراعملا ةديدجلا بطلا

2 2 ةصاخبو عورف ايجولويزلا ءايميكلاو ةيويحلا ايجولويبلاو ةيئيزجلا ملعو ىن بلا ةيثرا ولا قيبطتو كلت فراعملا لصوتلل جلاع لضفأ ضرا ملأل ةصاخبو.لا دقو زكرت يمامتها ىلع بناوجلا ةيمكلا بطلل امم ينداق صصختلا ملع لا اهتاسايقو ةقيقدلا ثيح نكمي حلاصإ للخلا ضعب لا اهضفخ اذإ تدزا نع.دحلا و ةيادب يتايح ةيملعلا - دعب يتدوع ةعماج ل ڤلا ا - تفشتكا نأ مادختسا ريظنلا طشنلا رصنعل ريرحت لسالا يذلا هجتني خملا ةرطيسلل ىلع طاشن لسالا هل ريثأت مهم روكذلا نأو همادختسا فقوي جاتنإ نومرهلا يركذلا امم لثمي اعون يصخلا يئايميكلا سو ك علا يضرمل. ناعرسو ام ل ح كلذ ناكم ةحرا جلا تاعرجلاو ةيلاعلا لا ةيوثنلأا تناك مدختست جلاع كئل ىضرملا رثكلأ نيعبرأ.اماع مث تقفو فاشتكا رخآ مهم وهو ن أ تايمك ةلئاه متي اهجاتنإ ةجسنلأا ةرطلا لثم كلذو بكرم لماخ هزرفت ةدغلا.ةيرظكلا ءانبو هيلع مت ليدعت جلاع لمشيل ع جاتنإ ةدغلا ةيرظكلا كلذو نود ةجاحلا اهتلزا إ ايحرا ج امو بترتي هيلع تافعاضم.ةريطخ امبو ن أ ىقبت جيسنلا يلا اتاتسوربلل دعب يصخلا يحرا جلا يئايميكلا تمق ةفاضإب رصنع داضم ل فاقيلإ اهريثأت ز فحملا ومنلل يلا تيمسأو كلت ةقيرطلا " عنام ب كر ملا " يهو ايلاح لضفأ ةقيرط - لب -ةديحولا جلاعل رشتلا امك اهنأ ةلاعف تلااح لا يعضوملا اذإ تمدختسا لحرا ملا ةركبملا.ضرملل مهأ ايزا م ةزئاج ةيملاعلا بطلا اهنأ ف رعت سانلا اصوصخو ةكلمملا ةيبرعلا ةيدوعسلا هذهب ةقيرطلا ةيجلاعلا ولخت دح ريبك تافعاضملا دعاستو ذاقنإ ةايح ديدعلا ىضرملا راوطلأا ةركبملا ل تنكو دق تحرش كلذ

3 3 ةرايز ةقباس يل ةكلمملا لبق عضب.تاونس نكمملا لاعف ذاقنإ ةايح ديدعلا ىضرملا نع قيرط صيخشتلا ركبملا ضرملل ةدافتسلااو قرطلا ةيجلاعلا ةرفوتملا ايلاح ءاوس ع جاتنإ ةحرا جلا جلاعلا.يعاعشلإا رركأ يركش مداخل نيمرحلا نيرشلا الله دبع نب دبع زيزعلا يلوو هدهع ريملأا ناطلس ةسسؤمو ةيريخلا ةزئاجو ةيملاعلا اذهل ميركتلا يقرا لا مركلاو.ضا لا هذه ةزئاجلا فوس نوكت زا فاح انل ريوطتل ديزملا قرطلا ةلاعفلا جلاعل كلذكو يدثلا طبترملا هلثم طاشنلاب ينومرهلا كلذو ام ىع سن هيلإ.ايلاح

4 Acceptance Speech of PROFESSOR FERNAND LABRIE Co-Winner of the 2007 King Faisal International Prize for Medicine Monday 16 April 2007 ( H) Your Royal Highness, Prince Sultan Ibn Abd Al Aziz Crown Prince, Deputy Premier, Minister of Defense and Aviation and Inspector General Your Highnesses Your Excellencies Distinguished Guests It is a unique honour to receive the King Faisal International Prize in Medicine, which strongly emphasizes the traditions of Arabic and Islamic philanthropy. It is indeed a great privilege to be associated to the list of personalities of such high reputation who received the King Faisal International Prize since the establishment of the Foundation in the honour of King Faisal in I am especially proud to be associated with the 2007 winners having such exceptional international reputation. The award of the King Faisal International Prize is not only an honour for me but it is also a major recognition and source of motivation for all my colleagues and collaborators who have been in hundreds over the years. It is also with great pride that I receive this prize that enlightens the reputation of my University, Laval University, as well as my city of residence, Quebec City, the oldest and most European city in North America. During all my education at the Petit Séminaire de Québec, at the Faculty of Medicine at Laval University, during my postdoctoral studies in Cambridge, England, my objective and passion have always been to search, as intensively as possible, for new knowledge in medicine, especially in 4

5 physiology, biochemistry, molecular biology and genomics, and to apply such knowledge to improving the treatment of diseases, cancer being my main target. My preference has always been for the quantitative aspects of medicine, a choice which led me to endocrinology or the science of hormones where we can measure with precision the level of hormones. On most occasions, we are able to replace the deficits of specific hormones or, in other cases, to decrease the excess of other hormones. I had the opportunity, early in my career, upon my return at Laval University, to discover that the administration of a superactive hormone, namely an analogue of gonadotropin-releasing hormone (GnRH), the brain hormone that controls both male and female gonads, had an important but unpredictable effect in men. We then found in 1980 that the administration of a superactive GnRH led to a complete blockade of male hormone formation by the testicles in men. This chemical castration could then be easily applied to patients suffering from prostate cancer. This discovery very rapidly replaced surgical castration and high doses of estrogens which had been the standard method of castration for the treatment of prostate cancer worldwide for more than 40 years. I then had another and probably more important chance by discovering that male hormones are not made exclusively by the testicles in men, as previously believed. In fact, an almost equal amount of male hormones are made in peripheral tissues, including the prostate from an inactive precursor, namely dehydroepiandrosterone (DHEA) secreted by the adrenal glands. With this knowledge, it became clear that the hormonal treatment of prostate cancer needed to change from an approach limited to castration to a blockade of the male hormones originating from both the testicles and those made locally in the prostate from the inactive precursor DHEA secreted by the adrenal glands. Since the adrenal glands cannot be removed without serious medical consequences, I decided to administer a blocker of the action of these male hormones, made locally in the prostate in order to prevent their action. The objective was to achieve the same effect with a drug as the one which could have been achieved by removal of the adrenal glands by surgery. 5

6 Based upon our discovery that 40 % to 50 % of male hormones remain in the prostate cancer tissue after surgical or medical castration, we have thus added an antiandrogen or blocker of the action of these male hormones which, otherwise, continued to stimulate prostate cancer after castration. We called the combination of castration with an antiandrogen combined androgen blockade. While combined androgen blockade is still the best and even the only treatment effective against metastatic disease, it is of major importance to indicate that the same combined androgen blockade can cure prostate cancer in the large proportion of cases when it is applied early when the cancer is localized inside the prostate or in close proximity to the prostate. This means that the cancer must be diagnosed early enough by screening in order to be treated before it spreads to the bone where cure is not possible. A major advantage of the King Faisal International Prize in medicine is the opportunity to make this medical treatment better known to the general population, first in Saudi Arabia where I came a few years ago to give lectures on combined androgen blockade and also to the whole world in order to permit all men to benefit from treatments which have minimal sideeffects and can save the lives of most patients diagnosed sufficiently early with prostate cancer. In fact, with early diagnosis which can be easily achieved by screening, the treatments currently available, including surgery, radiotherapy and combined androgen blockade can practically eliminate death from prostate cancer. I would like to thank the Custodian of the Two Holy Mosques, King Abd Allah Ibn Abdul Aziz Al-Saud, the King Faisal Foundation and the King Faisal International Prize for such a sophisticated kindness and generosity. This Prize will be a stimulus to further develop even more efficient therapies for prostate cancer and also for breast cancer, a cancer somewhat analogous to prostate cancer in terms of response to hormones. The development of new drugs for these two cancers is my current priority. 6

ملفّات مشابهة

(141) Ziyara [119] of lady Fatima al-ma ssooma (s) Peace be upon Adam, the choice of peace be upon Noah, the prophet of peace be upon Ibraheem (Abraham), the friend of peace be upon Musa (Moses), the speaker